Charmaine Demanuele

CEO

Cambridge, Massachusetts, United States15 yrs 3 mos experience
Highly StableAI Enabled

Key Highlights

  • Expert in multimodal neuroimaging techniques.
  • Leader in clinical trial innovation using digital health.
  • Strong background in statistics and machine learning.
Stackforce AI infers this person is a Healthcare Data Scientist specializing in neuroimaging and digital health technologies.

Contact

Skills

Core Skills

Data ScienceNeuroscienceClinical ResearchNeuroimaging

Other Skills

AI/ML methodologiesAlgorithmsArtificial Intelligence (AI)Blind source separationData AnalysisData analysisDigital HealthDigital health technologiesEEGLifesciencesMEGMachine LearningMachine learningMatlabMobile technology

About

I am a neuroscientist with a strong background in statistics and data science. As a postdoctoral research fellow, I employed multimodal neuroimaging (MRI, fMRI, EEG, MEG), and multivariate statistical and machine learning methods to illuminate cognitive processing and memory consolidation in the healthy brain and how these are impaired in schizophrenia. My current work is focused on the use of mobile and wearable technology coupled with novel statistical approaches to derive new digital endpoints for clinical trials. I am committed to help enhance our knowledge of complex diseases, accelerate drug discovery, and empower patients, caregivers and healthcare providers.

Experience

Johnson & johnson innovative medicine

Vice President, R&D Data Science & Digital Health - Neuroscience

May 2025Present · 10 mos · Cambridge, Massachusetts, United States · Hybrid

Data ScienceDigital HealthArtificial Intelligence (AI)NeuroscienceClinical Research

Pfizer

4 roles

Executive Director, Head of Quantitative Sciences for Digital Sciences & Translational Imaging

Promoted

Aug 2022May 2025 · 2 yrs 9 mos

  • As part of the Global Biometrics and Data Management organization in the AI/ML Digital and Quantitative Sciences Group within Global Product Development (GPD), I lead a team of statisticians and data scientists to enable end-to-end clinical trial innovation with imaging, digital health technologies and statistical, AI/ML methodologies. We work across Pfizer's early, late and established portfolio and leverage models such as Bring-Your-Own-Device and Decentralized Clinical Trials to enable efficient, patient-centric trials and faster breakthroughs for patients.
  • This team was part of Early Clinical Development (ECD) until December 2022

Senior Director, Head of Digital Medicine & Translational Imaging Statistics

Promoted

Dec 2021Aug 2022 · 8 mos

Director, Early Clinical Development Statistics

Promoted

Jan 2019Nov 2021 · 2 yrs 10 mos

  • My group sits within Early Clinical Development (ECD) Non-Clinical Statistics in Worldwide Research and Development. We work with ECD Digital Medicine and with research units to employ wearable, mobile and environmental sensor technology to impact clinical trials across Pfizer’s early, late, and established portfolios. We provide expertise on experimental design, data collection, data analysis, and on the development and application of state of the art statistical and machine learning methods for the discovery of new digital biomarkers from these technologies.

Associate Director of Biostatistics, Early Clinical Development, Neuroscience

Jun 2017Dec 2018 · 1 yr 6 mos

Biogen

Data Scientist

Aug 2016Jun 2017 · 10 mos · Cambridge, Massachusetts

  • I use data science to improve treatment discovery and delivery for patients suffering from neurodegenerative diseases.

Insight data science

Insight Health Data Science Fellow

Jan 2016Mar 2016 · 2 mos · Boston

  • Consulted for Constant Therapy and used SQL to mine data collected by their brain rehabilitation app
  • Delivered a framework that smoothens noisy behavioral data, selects features of interest from user's demographic and baseline performance and predicts user's improvement on tasks through linear, radial SVM and random forest regression
  • Developed an interactive front-end using Flask, Bootstrap css, HTML, jQuery, JSON and AJAX: www.therapyprospector.me

Martinos center for biomedical imaging, harvard medical school

Postdoctoral Research Fellow in Psychiatric Neuroimaging

Sep 2013Aug 2016 · 2 yrs 11 mos · Psychiatric Neuroimaging, Charlestown, MA

  • Developed data analysis pipelines comprising time-frequency analyses, blind source separation, source localization, k-means clustering and mixed model regression to investigate the mnemonic role of brain oscillations during sleep in health and schizophrenia
  • Executed data analyses of an NIH-funded pharmacological, clinical sleep study (~220 records, 8-hr sleep recordings), and data collection of an MEG-EEG study
  • Secured 2-year funding from the Brain & Behavior Research Foundation NARSAD Young Investigator Grant, and act as investigator on MGH-MIT Strategic Initiative’s Grand Challenge #3 on Neurosciences grant
  • Coached research assistants on clinical data collection and preprocessing

Bernstein center for computational neuroscience heidelberg-mannheim

Postdoctoral Researcher

Aug 2010Jul 2013 · 2 yrs 11 mos · Heidelberg, Baden-Württemberg, Germany

  • Employed supervised (multivariate test statistics and bootstraps) and unsupervised (Hidden Markov Models) approaches to discriminate task-specific information processing in various brain regions
  • Developed a feature extraction algorithm that builds on regularized linear discriminant analysis and finds maximally predictive feature set through a forward-backward procedure
  • Applied these methods to fMRI data (very high dimensional, sparse data with thousands of voxels and few time points) to study working memory and decision making in health and schizophrenia
  • Delivered lectures and tutorials on statistics and computational neuroscience at the University of Heidelberg to students from backgrounds as diverse as physics, mathematics, engineering, biology, psychology, and medicine
  • Coordinated weekly BCCN Heidelberg-Mannheim External Speaker Seminar Series

Education

University of Southampton

Doctor of Philosophy (Ph.D.)

Jan 2006Jan 2010

University of Malta

Bachelor of Engineering (B.Eng.) — Electrical Engineering

Jan 2002Jan 2006

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