Jan 2024 – Sep 2024 · 8 mos

• ▶︎ Modeled 6 hotspot mutations in the DNA-binding domain of p53, revealing steric hindrance and loss of hydrogen bonds, critical to understanding cancer progression.
• ▶︎ Utilized AlphaFold to compare wild-type and mutant p53 structures, demonstrating structural deviations with an RMSD of 5.024 Å
• ▶︎ Performed protein-DNA docking predictions with web-based serves like HDOCK
• ▶︎ Developed a workshop on Diffusion Models for Protein Generation for future versions of the class: Computational Protein Structure Prediction and Design
• Instructor: Dr.Jeffrey Gray

Aug 2023 – Jul 2025 · 1 yr 11 mos

• Thesis: Probing the Aging Effects of Vascular Cell-Matrix Interactions in Cardiovascular Disease
• Advisor: Dr. Lakshmi Santhanam
• ▶︎Showed the involvement of Loxl2 protein in Pulmonary Hypertension through LC-MS/MS proteomics data.
• ▶︎Developed a strategy to study age related changes in the arteries based on 2 key factors of cardiovascular disease.
• ▶︎Managed 6+ mouse colonies, ensuring genetic consistency and effective data recording

Aug 2023 – Dec 2023 · 4 mos

• ▶︎ Developed PK models from first principles for the distribution of drugs targeting multiple myeloma.
• ▶︎ Captured the experimental concentration profiles of 3 antibody drugs within 5% error.
• ▶︎ Created PBPK based toxicity profiles for 8 different organs based on data from clinical trials and literature review.
• ▶︎ Implemented Target Mediated Drug Deposition Model for Isatuximab and accounted for observed drug resistance.
• ▶︎ Carried out a comparative study between patient conditions, treatment regimens and serum factors based on pharmacodynamics data.
• Advisor: Dr. Marc Donohue

Jan 2023 – Jun 2023 · 5 mos

• Project: Off-target DNAse Activity of Cas12a | Dr. Ashok Sekhar
• Poster at India Alliance, DBT Trust 2023
• ▶︎ Developed and sequenced plasmid libraries for expression of CRISPR-Cas12a enzyme.
• ▶︎ Optimized the expression of the enzyme in bacterial host and confirmed functionality using enzymatic assays.
• ▶︎ Optimized the staining and imaging of Cas12a enzyme using negative staining for structure elucidation.

Jun 2022 – Jan 2023 · 7 mos

• Project: Drug Delivery For Chronic Osteoarthritis | Dr. Rachit Agarwal
• ▶︎ Characterized microparticle drug properties, achieving 30% improvement in treatment
• ▶︎ Boosted liposome drug loading by 20% by applying active loading techniques.
• ▶︎ Ensured strict adherence to drug quality ( > 90% pure) using HPLC and DLS techniques.

Mar 2022 – Jun 2022 · 3 mos

• Project: Biodegradable Plastic Development & Scale Up | Dr. Kartikeya Shukla
• ▶︎ Optimized starch gelatinization from 2 sources for biodegradable plastic production.
• ▶︎ Analyzed the impact of additives like glycerol and oil on properties such as hydrophobicity, mechanical strength, and opacity.
• ▶︎Cost analysis for scale-up and industrial production, assessing time for profit return and feasibility.

Jun 2021 – May 2022 · 11 mos

• ▶︎ Spearheaded 5+ events to advocate for women in STEM, boosting participation by 30%
• ▶︎ Launched the YouTube series ‘Tech PropelHers’ to share the contributions of women to STEM
• ▶︎ Mentored 2 aspiring researchers, providing personalized guidance on career development and skill-building

Mar 2021 – Jan 2022 · 10 mos

• Project: Antibody Design for Parkinson's Disease
• Advisor: Dr. Gaurav Goel
• ▶︎ Evaluated the efficacy of 10+ antibodies for the treatment of Parkinson’s disease through docking calculation on Hex and Rosetta.
• ▶︎ Quantified the impact of the therapy in halting disease progression based on binding interactions.
• ▶︎ Implemented modifications to the epitope of ‘Aducanumab’ to improve potency by 15%.

Dec 2019 – Mar 2020 · 3 mos

• Project: Computational Model for Alzheimer’s Disease
• ▶︎ Developed a mathematical MATLAB model for the brain using patient data gathered from patient experiments and quantified 10+ parameters involved in signalling.
• ▶︎ Predicted neuron death due to hormone imbalance with 90% accuracy compared to patient data.
• https://sites.google.com/view/bgx/team?authuser=0#h.p_2-M_wxndXBB4